Antifungal therapy with an emphasis on biofilms

作者：Pierce Christopher G; Srinivasan Anand; Uppuluri Priya; Ramasubramanian Anand K; Lopez Ribot Jose L^*

来源：Current Opinion in Pharmacology, 2013, 13(5): 726-730.

DOI：10.1016/j.coph.2013.08.008

Fungal infections are on the rise as advances in modern medicine prolong the lives of severely ill patients. Fungi are eukaryotic organisms and there are a limited number of targets for antifungal drug development; as a result the antifungal arsenal is exceedingly limited. Azoles, polyenes and echinocandins Constitute the mainstay of antifungal therapy for patients with life-threatening mycoses. One of the main factors complicating antifungal therapy is the formation of fungal biofilms, microbial communities displaying resistance to most antifungal agents. A better understanding of fungal biofilms provides for new opportunities for the development of urgently needed novel antifungal agents and strategies.

• 出版日期2013-10