ASSOCIATION OF RESISTIN GENE 3 ' UTR+62G > A POLYMORPHISM WITH INSULIN RESISTANCE, ADIPOSITY AND THE ADIPONECTIN-RESISTIN INDEX IN MEXICAN POPULATION

作者：Chavarria Avila Efrain; Ruiz Quezada Sandra Luz; Guzman Ornelas Milton Omar; Castro Albarran Jorge; Aguilar Aldrete Maria Elena; Vasquez Del Mercado Monica; Navarro Hernandez Rosa Elena^*

来源：Nutricion Hospitalaria, 2013, 28(6): 1867-1876.

DOI：10.3305/nh.2013.28.6.6912

• Insulin resistance
• Adiposity
• Adiponectin
• Resistin
• Polymorphism RETN 3 ' UTR+62G &gt
• A

Introduction: Insulin resistance (TR) is a disease with genetic susceptibility characterized by the increase in storage and irregular body fat distribution, and impaired production of adipokines.
Objective: The objective was to investigate the relationship between 3'UTR+62G>A RETN gene polymorphism, with adiponectin-resistin index (AR(index)), adiposity, and inmuno-metabolic markers.
Methods: In this cross-sectional study, 260 individuals characterized as Mexican-Mestizo and classified in lean and overweight, and IR and without-IR, were included. Anthropometrics, body composition, body fat distribution and inflammation and metabolic markers were measured by routine methods, RETN 3'UTR+62G>A alleles were identified by PCR-RFLP and soluble insulin, total adiponectin and resistin were measured by ELEA methods.
Results: The +62G allele frequencies for lean and overweight individuals were different P = 0.0343 (95.4% and 98.4%, respectively). The lean GA genotype carriers showed significant low measures of AR(index), adiposity, and inmuno-metabolic markers, than the GG genotype carriers. We found differences between individuals with IR and without-IR: in AR(index) (P = 0.002), adiponectin (P = 0.002) and resistin levels (P = 0.033): 1.102 +/- 0.03, 5.167 +/- 0.36 mu g/mL and 8.827 +/- 0.42 ng/mL versus 1336 +/- 0.07, 3.577 +/- 0.34 mu g/mL and 10.480 +/- 0.65 ng/mL. Showed correlations with inflammation markers, distribution and body fat storage (r=0.262 to 0.414), P<0.05.
Conclusions: The present data suggest that in a Mexican-mestizo population the RETN +62G>A polymorphism is associated with overweight. The presence of the +62A allele was associated with increase of total adiponectin, AR(index), resistin levels, metabolic markers and body fat storage. AR(index) can be an early indicator of insulin resistance.

• 出版日期2013-12