Design, synthesis, and insecticidal bioactivities evaluation of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring

作者：Shen, Bong-Feng; Chen, Xi; Liao, Pin; Shao, Xu-Shen; Li, Zhong; Xu, Xiao-Yong^*

来源：Chinese Chemical Letters, 2015, 26(5): 509-512.

DOI：10.1016/j.cclet.2015.03.017

• Neonicotinoid
• Pyrrole
• Dihydropyrrole
• Insecticidal activity

Chlorothiazole ring, as a substituted heterocycle, frequently occurred in structures of various insecticides, and brought positive effect on bioactivity. In purpose to find novel neonicotinoids, a series of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring were synthesized for the first time. Results of the following biological assays showed that compounds 5a-c achieved good insecticidal activity against Aphis craccivora, and compound 5h exhibited good activity against Nilaparvata lugens.

• 出版日期2015-5
• 单位华东理工大学