Association of genetic variants in SEMA3F, CLEC16A, LAMA3, and PCSK2 with myocardial infarction in Japanese individuals

作者：Fujimaki Tetsuo; Kato Kimihiko; Yokoi Kiyoshi; Oguri Mitsutoshi; Yoshida Tetsuro; Watanabe Sachiro; Metoki Norifumi; Yoshida Hidemi; Satoh Kei; Aoyagi Yukitoshi; Nozawa Yoshinori; Kimura Genjiro; Yamada Yoshiji^*

来源：Atherosclerosis, 2010, 210(2): 468-473.

DOI：10.1016/j.atherosclerosis.2009.11.050

• Myocardial infarction
• Coronary heart disease
• Atherosclerosis
• Genetics
• Polymorphism

Objective: The purpose of the present study was to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese individuals.
Methods: The study population comprised 5014 Japanese individuals, including 1444 subjects with MI and 3570 controls. The 150 polymorphisms examined in the present study were selected by a genome-wide association study for ischemic stroke with the use of the GeneChip Human Mapping 500K Array Set (Affymetrix), and were determined by a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology.
Results: An initial screen by the chi-square test revealed that the A -> G polymorphism of SEMA3F (rs12632110), the C -> T polymorphism of CLEC16A (rs9925481), the A -> G polymorphism of LAMA3 (rs12373237), and the C -> G polymorphism of PCSK2 (rs6080699) were significantly (false discovery rate for allele frequencies of <0.05) associated with MI. Subsequent multivariable logistic regression analysis with adjustment for covariates and a stepwise forward selection procedure revealed that the A -> G polymorphism of SEMA3F (dominant model; P = 0.0014; odds ratio, 0.76), the C -> T polymorphism of CLEC16A (dominant model; P = 0.0009; odds ratio, 0.75), the A -> G polymorphism of LAMA3 (recessive model; P = 0.0099; odds ratio, 0.80), and the C -> G polymorphism of PCSK2 (recessive model; P = 0.0155; odds ratio, 1.19) were significantly (P < 0.05) associated with the prevalence of MI.
Conclusion: Determination of these genotypes may prove informative for assessment of the genetic risk for MI in Japanese individuals.

• 出版日期2010-6