An alternate method for the synthesis of 2-aryl/alkyl-5-bromo-7-methoxy benzofurans; application to the synthesis of Egonol, Homoegonol, and analogs via Heck reaction

作者：More Kishor R^*; Mali R S

来源：Tetrahedron, 2016, 72(47): 7496-7504.

DOI：10.1016/j.tet.2016.09.068

• 2-Aryl/alkyl-5-bromo-7-methoxy benzofurans
• Egonol
• Homoegonol
• Heck reaction
• Synthesis

We herein report the general, versatile, and convenient method for the synthesis of 2-arly/alkyl-5-bromo-7-methoxy benzofurans from easily available o-Vanillin in five steps. These benzofurans was successfully converted into biological active natural products Egonol, Homoegonol, and analogous on applying Heck reaction using ethyl/methyl acrylate in the presence of palladium catalyst.

• 出版日期2016-11-24