A microelectronic portal imaging device for image guided conformal microirradiation of murine cancer models

作者：Price Samantha G; Silvius Alexander A; Izaguirre Enrique W^*

来源：Journal of X-Ray Science and Technology, 2014, 22(5): 551-567.

DOI：10.3233/XST-140445

• Preclinical radiobiology
• microirradiator
• high resolution imaging
• orthovoltage imaging

Image guided conformal small animal orthovoltage microirradiators are currently under development to perform radiobiological experiments with preclinical cancer models. An important component of these instruments is the treatment delivery image guidance system, a microelectronic portal imaging device (mu EPID). Here, we present the design and implementation of a mu EPID, specifically designed and constructed for small animal orthovoltage microirradiators. The mu EPID can acquire images in the range of 60 kVp to 320 kVp x-ray photon energies and can endure high doses from orthovoltage beams without radiation damage. The mu EPID can acquire 200 mu m resolution images at a rate of 17 frames per second for online in vivo co-registration between irradiation beams and small animal anatomy. An exposure with less than 1% of a 2 Gy treatment field is required for imaging, which is an adequate ratio between imaging dose and treatment dose to avoid undesired irradiation of healthy tissue or alteration of the preclinical cancer model. The mu EPID was calibrated for microdosimetry with a precision of 4.1% with respect to an ion chamber, used as a gold standard. To validate the in vivo device performance, irradiations of lung, brain, and xenograft breast cancer preclinical models were performed and analyzed.

• 出版日期2014