Phytochemical Investigation of Verbesina turbacensis Kunth: Trypanosome Cysteine Protease Inhibition by (-)-Bornyl Esters

作者：Ogungbe Ifedayo V; Crouch Rebecca A; Haber William A; Setzer William N^*

来源：Natural Product Communications, 2010, 5(8): 1161-1166.

• Verbesina turbacensis
• essential oil
• (-)-bornyl esters
• rhodesain
• trypanosomiasis

The bark and leaf essential oils of Verbesina turbacensis were obtained by hydrodistillation and analyzed by GC-MS. The bark oil of the plant was composed mainly of monoterpene hydrocarbons (83.5-90.4%), predominately alpha-pinene, while the leaf oil was composed mainly of sesquiterpene hydrocarbons, dominated by germacrene-D (29.1-36.9%), and delta-elemene (21.7-22.1%). Three bornyl hydroxycinnamic esters isolated from the acetone bark extract were found to inhibit the cysteine protease, rhodesain. Molecular docking analysis to probe the inhibitory interactions of the esters was also carried out.

• 出版日期2010-8