An organocatalytic direct Mannich-cyclization cascade as [3+2] annulation: asymmetric synthesis of 2,3-substituted pyrrolidines

作者：Kumar Indresh^*; Mir Nisar A; Gupta Vivek K; Rajnikant

来源：Chemical communications, 2012, 48(55): 6975-6977.

DOI：10.1039/c2cc33103a

A new method for asymmetric synthesis of 2,3-substituted pyrrolidines from N-PMP aldimines and succinaldehyde via formal [3 + 2] cycloaddition is reported. This reaction involves proline catalyzed direct Mannich reaction and acid catalyzed reductive cyclization with high yields (up to 78%) and excellent enantioselectivities (up to > 99%).

• 出版日期2012