科研之友
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摘要
A simple and efficient strategy for direct regioselective esterification at O-2 of beta-cyclodextrin was developed by using the combination of N, N'-carbonyldiimidazole and carbonate buffer in 1,4-dioxane, which does not require large amounts of polar organic solvents such as DMF, toxic solvents such as CH3CN, or flammable bases such as NaH. Moreover, their hydrolyses by neighboring-group participation were observed. Mono-2-tosyl-beta-cyclodextrin was liable to epoxidation, while mono-2-(p-methylbenzoyl)-beta-cyclodextrin liable to isomerization. They had different mechanisms of hydrolysis.
- 出版日期2012
- 单位宁夏医科大学
