An investigation of damage mechanisms in mechanobiological models of in-stent restenosis

作者：Nolan David R; Lally Caitrioria^*

来源：Journal of Computational Science, 2018, 24: 132-142.

DOI：10.1016/j.jocs.2017.04.009

• Agent based model
• Finite element
• Restenosis
• Stent
• Mechanobiology

The mechanisms behind in-stent restenosis, the re-narrowing of a stented artery, are poorly understood. However it is known that mechanical damage due to stent implantation plays a major role. This paper investigates the mechanism behind damage-induced cell proliferation using a coupled finite element and agent based model, assuming it is based on a) instantaneous loading, or b) cyclic loading. Furthermore the role of remnant endothelial cells in attenuating in-stent restenosis is examined. Results show that a cyclic damage model predicts a non-physiological, overly proliferative response, whilst the instantaneous model demonstrates that lumen loss may be regulated by re-endothelialisation.

• 出版日期2018-1