Design, synthesis and biological evaluation of new ionone derivatives as potential neuroprotective agents in cerebral ischemia

作者：Srivastava Ajay Kumar; Dohare Preeti; Ray Madhur; Panda Gautam^*

来源：European Journal of Medicinal Chemistry, 2010, 45(5): 1964-1971.

DOI：10.1016/j.ejmech.2010.01.039

• Ionone
• Allylic alcohol
• Cerebral ischemia
• Stroke

A new series of ionone derived allylic alcohols have been evaluated for anti-ischemic activity. Out of them, 121 and 13b decreased infarct volume to 23.98 +/- 4.7 mm(3) and 93.98 /- 24.8 mm(3) as compared to ischemic group.

• 出版日期2010-5