Fabrication of functionalized porous silica nanoparticles and their controlled release behavior

作者：Zhang, Xu; Zhao, Yanbao^*; Xie, Songqiang; Sun, Lei

来源：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2017, 37: 38-45.

DOI：10.1016/j.jddst.2016.11.005

• Porous silica
• Nanocarriers
• Hemolytic activity
• Redox-responsive
• Drug delivery

Thiol and amine difunctionalized porous silica (pSiO(2)-SH/NH2) nanoparticles (NPs) were prepared by condensation. The obtained pSiO(2)-SH/NH2 NPs present uniform spheres with size of 55 nm. Folic acid (FA) as a tumor targeting agent was conjugated on the surface of pSiO(2) NPs by amide linkage (pSiO(2)-SH/FA NPs), and captopril (Cap) as test drug was used to evaluate the releasing behavior. Results indicated that Cap is easily encapsulated into the pores of pSiO(2)-SH/FA NPs, which can further react with the inner thiols to form disulfide bonds. The Cap release from pSiO(2)-Cap/FA nanocarriers can be controlled by dithiothreitol (DTT) or reduced glutathione (GSH). The pSiO(2)-SH/FA nanocarriers showed low cytotoxicity and redox-responsive drug release.

• 出版日期2017-2
• 单位河南大学