Elucidating the interplay between IgG-Fc valency and Fc gamma R activation for the design of immune complex inhibitors

作者：Ortiz Daniel F; Lansing Jonathan C; Rutitzky Laura; Kurtagic Elma; Prod'homme Thomas; Choudhury Amit; Washburn Nathaniel; Bhatnagar Naveen; Beneduce Christopher; Holte Kimberly; Prenovitz Robert; Child Matthew; Killough Jason; Tyler Steven; Brown Julia; Nguyen Stephanie; Schwab Inessa; Hains Maurice; Meccariello Robin; Markowitz Lynn; Wang Jing; Zouaoui Radouane; Simpson Allison; Schultes Birgit; Capila Ishan; Ling Leona; Nimmerjahn Falk; Manning Anthony M

来源：Science Translational Medicine, 2016, 8(365): 365ra158.

DOI：10.1126/scitranslmed.aaf9418

<jats:p>An engineered trivalent Fc drug candidate is a potent inhibitor of FcγR-driven immune cell activation and autoimmune diseases in animal models.</jats:p>

• 出版日期2016-11-16