Atypical Fractures of the Femur Related to Prolonged Treatment with Bisphosphonates for Osteoporosis

作者：Rosenthal Yoav^*; Arami Amir; Kosashvili Yona; Cohen Nir; Sidon Eli; Velkes Steven

来源：Israel Medical Association Journal, 2014, 16(2): 78-82.

• bisphosphonates
• subtrochanteric fracture
• atypical fracture
• osteoporosis
• femur

Background: Bisphosphonates reduce the overall risk of fractures among patients with osteoporosis, and this beneficial effect is long-lasting. However, since bisphosphonates inhibit bone remodeling, they may enhance the formation and propagation of micro-cracks over time and patients May therefore be prone to atypical fatigue fractures, mainly in the subtrochanteric region and femoral shaft.
Objectives: To present two cases of subtrochanteric fractures related to bisphosphonate treatment, and review the current literature.
Conclusions: Despite the overall beneficial effect of bisphosphonates, further research is required to prevent this significant complication.

• 出版日期2014-2