DABCO catalyzed highly regioselective synthesis of fused imidazo-heterocycles in aqueous medium

作者：Bangade Vikas M; Reddy B Chennakesava; Thakur Pramod B; Babu B Madhu; Meshram H M^*

来源：Tetrahedron Letters, 2013, 54(35): 4767-4771.

DOI：10.1016/j.tetlet.2013.06.123

• Phenacyl bromide
• 2-Aminopyridine
• Regioselectivity
• Fused imidazo-heterocycles
• DABCO
• Water

An efficient regioselective synthesis of 3-aryl imidazol[1,2-a]pyridines, 5-aryl imidazo[2,1-b]thiazoles, and 3-aryl benzo[d]imidazo[2,1-b][1,3]thiazoles is described by the reaction of phenacyl bromide with heterocyclic amine in the presence of DABCO under aqueous medium. The method is applicable for a variety of substituted phenacyl bromides as well as 2-amino-heterocycles. An aqueous reaction medium, regioselectivity, mild reaction condition, and high yield of products are the important features of this protocol.

• 出版日期2013-8-28