A novel biomarker explaining the role of oxidative stress in exercise and L-tyrosine supplementation: thiol/disulphide homeostasis

作者:Kayacan Yildirim*; Yazar Hayrullah; Kisa Emin Can; Ghojebeigloo Babak Elmi
来源:Archives of Physiology and Biochemistry, 2018, 124(3): 232-236.
DOI:10.1080/13813455.2017.1388410

摘要

The present study aimed to evaluate the relationship between exercise and both l-tyrosine and oxidative stress using thiol/disulphide homeostasis via a novel biomarker in rats. Following the completion of the exercise and l-tyrosine protocol, serum total thiol, native thiol, and disulphide concentrations were determined using a novel automated measurement method. Compared with the control group, serum dynamic disulphide levels were significantly lower in the E group (116.75 +/- 10.49; p <.05) and the highest in the LT group (151.0 +/- 5.84). The lowest oxidised thiol (49.75 +/- 6.18; p = .087) and the highest reduced thiol (75.38 +/- 3.16; p = .079) rates were determined to be in the E group. The highest oxidised thiol value was observed in the LT group. Exercise positively affects thiol/disulphide homeostasis, which is a novel indicator of oxidant-antioxidant parameters. Additionally, L-tyrosine appears to be more convenient combined with exercise. The new method used in our study proposes a promising, practical, and useful method for assessing the oxidative stress parameters.

  • 出版日期2018