Asymmetric total syntheses of xanthatin and 11,13-dihydroxanthatin using a stereocontrolled conjugate allylation to gamma-butenolide

作者：Matsumoto Kenji; Koyachi Kuniyoshi; Shindo Mitsuru^*

来源：Tetrahedron, 2013, 69(3): 1043-1049.

DOI：10.1016/j.tet.2012.11.077

• Xanthanolides
• Sesquiterpene lactones
• Total synthesis
• Conjugate allylation

The stereocontrolled conjugate allylation to an optically pure gamma-butenolide provided direct and reliable access to a trans-fused series of xanthanolide sesquiterpenoids and allowed for the enantioselective total syntheses of xanthatin and 11,13-dihydroxanthatin to be efficiently achieved.

• 出版日期2013-1-21