A multichannel thiacalix[4]arene-based fluorescent chemosensor for Zn2+, F- ions and imaging of living cells

作者：Ran, Mao-Qian; Yuan, Jian-Ying; Zhao, Yuan-Hui; Mou, Lan; Zeng, Xi^*; Redshaw, Carl; Zhao, Jiang Lin; Yamato, Takehiko

来源：Supramolecular Chemistry, 2016, 28(5-6): 418-426.

DOI：10.1080/10610278.2015.1109645

• colorimetric and fluorescent sensor
• Thiacalix[4]arene derivative
• Zn2+
• cell imaging
• F-

The fluorescent sensor (3) based on the 1,3-alternate conformation of the thiacalix[4]arene bearing the coumarin fluorophore, appended via an imino group, has been synthesised. Sensing properties were evaluated in terms of a colorimetric and fluorescence sensor for Zn2+ and F-. High selectivity and excellent sensitivity were exhibited, and 'off-on' optical behaviour in different media was observed. All changes were visible to the naked eye, whilst the presence of the Zn2+ and F- induces fluorescence enhancement and the formation of a 1:1 complex with 3. In addition, 3 exhibits low cytotoxicity and good cell permeability and can readily be employed for assessing the change of intracellular levels of Zn2+ and F-.

• 出版日期2016-6-2
• 单位贵州大学