Antitumor properties of Boswellic acid against Ehrlich ascites cells bearing mouse

作者：Agrawal S S^*; Saraswati Santa; Mathur Rajani; Pandey Maneesha

来源：Food and Chemical Toxicology, 2011, 49(9): 1924-1934.

DOI：10.1016/j.fct.2011.04.007

• Boswellic acid
• VEGF
• Ehrlich ascites tumor
• Caspase-3
• Angiogenesis

Boswellic acid (BA), a triterpene, isolated from Boswellia serrata (Burseraceae) has been found to possess potent anti-inflammatory and anti-cancer activity. The present study aimed at exploring the possible role of BA on ascites and solid Ehrlich tumor. Ascitic tumor development was evaluated 14 d after tumor implantation by quantification of the ascitic fluid volume whereas solid tumor was evaluated after 30 d tumor implantation by H&E and IHC. The i.p. administration of BA significantly inhibited ascitic and solid Ehrlich tumor model. This inhibition was observed with reduced ascitic volume, solid tumor volume and body weight when compared to control mice. The treatments also increased the survival of tumor-bearing mice. VEGF and TNF- alpha levels were decreased, whereas the IL-12 levels were increased with BA treatment at 25 mg/kg. Further, results on decrease in the peritoneal angiogenesis and microvessel density showed the anti-angiogenic potential. Microscopic examination of tumors revealed that in BA-treated groups the expression of Bax and caspase 3 increased, suggesting drug induced tumor cell apoptosis through activating the pro-apoptotic bcl-2 family and caspase-3. The present study sheds light on the potent antitumor property of the boswellic acid and can be extended further to develop therapeutic protocols for treatment of cancer.

• 出版日期2011-9