Anion Recognition as a Supramolecular Switch of Cell Internalization

作者:Rodriguez Jessica; Mosquera Jesus; Couceiro Jose R; Nitschke Jonathan R; Eugenio Vazquez M; Mascarenas Jose L
来源:Journal of the American Chemical Society, 2017, 139(1): 55-58.
DOI:10.1021/jacs.6b11103

摘要

The cell internalization of designed oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular host. This host binds specifically to the pyranine moiety, enabling the complex to traverse the cell membrane. Interestingly, none of the components, neither the host nor the guest, are able to cross the cell membrane on their own.

  • 出版日期2017-1-11