A single administration of fish oil inhibits the acute inflammatory response in rats

作者：Milani de Arruda Laura Licia; Ames Franciele Queiroz; de Morais Damila Rodrigues; Grespan Renata; Maziero Gil Ana Paula; Covas Pereira Silva Maria Angelica Raffaini; Visentainer Jesui Vergilio; Nakamura Cuman Roberto Kenji; Bersani Amado Ciomar Aparecida^*

来源：Asian Pacific Journal of Tropical Medicine, 2017, 10(8): 830-837.

DOI：10.1016/j.apjtm.2017.07.019

• Omega-3 fatty acid
• Polyunsaturated fatty acid
• Pleurisy
• Leukocyte migration
• EPA
• DHA

Objective: To investigate the anti inflammatory effects of a single administration of fish oil (FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil (FOP) orally administered in a single dose in rats. Nitric oxide (NO) concentrations in the pleural exudate were performed according to the Griess method and the cyrokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment (30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5,75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP (300 nig/kg) reduced NO, TNF-alpha, IL-I beta, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein.

• 出版日期2017-8