Association of the AKR1C3 polymorphism with cancer risk: a meta-analysis and systematic review

作者：Zhu Guangwei; Lin Yongxin; Ye Siting; Huang Yongjian; Zheng Wei; Hua Jin; Yang Shugang; Zhuang Jinfu; Wang Jinzhou; Ye Jianxin^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(9): 12960-+.

• AKR1C3
• gene
• polymorphism
• cancer
• meta-analysis
• systematic review

A number of studies investigating the association between AKR1C3 gene polymorphisms and the risks of cancer have yielded conflicting results. Therefore, we performed a meta-analysis to evaluate the effect of AKR1C3 gene single nucleotide polymorphisms on risk of all cancer types. A literature search was conducted to identify the relevant studies from PubMed, EMbase, OVID, and CMB databases. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. This meta-analysis included a total of 12 studies. In the combined results, no significant association was observed between the AKR1C3 rs12529 polymorphism with cancer risks. But the results of subgroup analysis of rs12529 showed a significant association in Asians (allele G vs allele C, OR=1.64, 95% CI 1.13-2.38, P=0.009; CG+GG vs CC, OR=1.78, 95% CI 1.03-3.07, P=0.04). In addition, significant association was observed between rs3763676 with cancer risk (GA+GG vs AA, OR=1.20, 95% CI 1.03-1.40, P=0.02). In regard to rs4881400, rs2245191 and rs12387, no significant association was observed between these polymorphisms with cancer risk. Results of the current meta-analysis suggest that rs12529 G allele might be associated with increased risk of cancer in Asians but not in other populations. In addition, carrying the rs3763676 G allele may be a potential risk factor of cancer. While rs4881400, rs2245191 and rs12387 polymorphisms were not associated with cancer risk. Further studies with larger sample sizes are needed to confirm these results.

• 出版日期2017
• 单位福建医科大学