Gold-Catalyzed Sequential Alkyne Activation: One-Pot Synthesis of NH-Carbazoles via Cascade Hydroarylation of Alkyne/6-Endo-Dig Carbocyclization Reactions

作者：Samala Srinivas; Mandadapu Anil K; Saifuddin Mohammad; Kundu Bijoy^*

来源：Journal of Organic Chemistry, 2013, 78(13): 6769-6774.

DOI：10.1021/jo400799b

A simple and efficient one pot protocol for the synthesis of NH-carbazoles has been described. The strategy comprises a one-pot reaction involving the treatment of 2-alkynyl indoles with arylacetylenes in the presence of an Au-Ag combination catalyst. The salient feature of the strategy involves sequential activation of terminal and internal alkynes leading to the cascade hydroarylation of terminal alkynes and 6-endo-dig carbocyclization reactions. The generality of the method has been demonstrated by using a series of 2-alkynyl indoles and arylacetylenes.

• 出版日期2013-7-5