Animal models of glucocorticoid-induced glaucoma

作者：Overby Darryl R; Clark Abbot F^*

来源：Experimental Eye Research, 2015, 141: 15-22.

DOI：10.1016/j.exer.2015.06.002

• Glucocorticoid
• Ocular hypertension
• Glaucoma
• Intraocular pressure
• Steroid glaucoma

Glucocorticoid (GC) therapy is widely used to treat a variety of inflammatory diseases and conditions. While unmatched in their anti-inflammatory and immunosuppressive activities, GC therapy is often associated with the significant ocular side effect of GC-induced ocular hypertension (OHT) and iatrogenic open-angle glaucoma. Investigators have generated GC-induced OHT and glaucoma in at least 8 different species besides man. These models mimic many features of this condition in man and provide morphologic and molecular insights into the pathogenesis of GC-OHT. In addition, there are many clinical, morphological, and molecular similarities between GC-induced glaucoma and primary open-angle glaucoma (POAG), making animals models of GC-induced OHT and glaucoma attractive models in which to study specific aspects of POAG.

• 出版日期2015-12