Development and characterization of nanostructured lipid carriers based chitosan thermosensitive hydrogel for delivery of dexamethasone

作者：Tan, Guoxin; Yu, Shihui; Li, Jinyu; Pan, Weisan^*

来源：International Journal of Biological Macromolecules, 2017, 103: 941-947.

DOI：10.1016/j.ijbiomac.2017.05.132

• Ocular drug delivery
• Nanostructured lipid carriers
• Quaternized chitosan
• Thermosensitive hydrogel
• Sustained release

This study aims to explore a novel composite thermosensitive in situ gelling formulation which the nanostructured lipid carriers (NLC) was incorporated into hydroxypropyltrimethyl ammonium chloride chitosan (HACC)-based hydrogels, and the resulting formulation investigated for its potential to act as a potential sustained ocular delivery system. NLC formulation loaded with dexamethasone (DXM) were prepared using the melt-emulsification method. The particle size, zeta potential, encapsulation efficiency, and morphological properties of the NLC were characterized. The HACC was synthesized and structure was analyzed by FT-IR and H-1 NMR. A thermosensitive hydrogel was designed and prepared by simply mixing HACC and beta-glycerophosphate (beta-GP). The obtained formulation showed a rapid solution-to-gel transition at 35 degrees C. The NLC were then incorporated in HACC/beta-GP hydrogel to form a NLC-loaded hydrogel carrier. In vitro release studies, 88.65% of total DXM was released from the NLC-HACC/GP gel within 3 days, indicating DXM-based NLC-gel could release drug sustainably. Taken together, DXM-based NLC-HACC/GP gel is a promising drug delivery system.

• 出版日期2017-10
• 单位沈阳药科大学