Molecular Epidemiology and Genetic Characteristics of Various blaPER Genes in Shanghai, China

作者：Xie, Lianyan; Wu, Jun; Zhang, Fangfang; Han, Lizhong; Guo, Xiaokui; Ni, Yuxing; Sun, Jingyong^*

来源：Antimicrobial Agents and Chemotherapy, 2016, 60(6): 3849-3853.

DOI：10.1128/AAC.00258-16

• SPECTRUM-BETA-LACTAMASE
• ACINETOBACTER-BAUMANNII
• PER-1
• EMERGENCE
• RESISTANT
• DIVERSITY
• STRAIN
• SPP.

We describe the genetic characteristics and possible transmission mechanism of bla(PER) in 25 clinical Gram-negative bacilli in Shanghai. bla(PER), including bla(PER-1), bla(PER-3), and bla(PER-4), was located chromosomally or in different plasmids. Tn1213 harboring blaPER-1 was first identified in two Proteus mirabilis isolates in China. The other bla(PER) variants were preceded by an ISCR1 element inside the complex class 1 integron associated with IS26, Tn21, Tn1696, and a miniature inverted-repeat transposable element.

• 出版日期2016-6
• 单位上海市闵行区中心医院; 河北医科大学; 上海交通大学