Analyzing marginal cases in differential shotgun proteomics

作者:Carvalho Paulo C*; Fischer Juliana S G; Perales Jonas; Yates John R; Barbosa Valmir C; Bareinboim Elias
来源:Bioinformatics, 2011, 27(2): 275-276.
DOI:10.1093/bioinformatics/btq632

摘要

We present an approach to statistically pinpoint differentially expressed proteins that have quantitation values near the quantitation threshold and are not identified in all replicates (marginal cases). Our method uses a Bayesian strategy to combine parametric statistics with an empirical distribution built from the reproducibility quality of the technical replicates.

  • 出版日期2011-1-15