Depressive Symptom Trajectory Predicts 1-Year Health-Related Quality of Life in Patients With Heart Failure

作者：Dekker Rebecca L^*; Lennie Terry A; Albert Nancy M; Rayens Mary K; Chung Misook L; Wu Jia Rong; Song Eun Kyeung; Moser Debra K

来源：Journal of Cardiac Failure, 2011, 17(9): 755-763.

DOI：10.1016/j.cardfail.2011.04.016

• Cardiovascular
• depression

Background: One-third of patients with heart failure (HF) experience depressive symptoms that adversely affect health-related quality of life (HRQOL). We aimed to describe depressive symptom trajectory and determine whether a change in depressive symptoms predicts subsequent HRQOL.
Methods and Results: The sample consisted of 256 inpatients and outpatients with HF. Depressive symptoms were measured at baseline and 3 or 6 months with the Patient Health Questionnaire (PHQ-9). The Minnesota Living with HF Questionnaire was used to assess HRQOL at baseline, 3 to 6 months, and 1 year. Based on baseline and 3- to 6-month PHQ-9 scores, patients were categorized as depressive symptom-free (64%), depressive symptoms improved (15%), depressive symptoms developed (6%), or persistent depressive symptoms (15%). The groups differed in 1-year HRQOL levels (F = 36, P < .001); patients who were depressive symptom-free or whose depressive symptoms improved had better 1-year HRQOL than patients with persistent depressive symptoms (Tukey honestly significant difference, P < .01). Change in depressive symptoms was the strongest predictor of 1-year HRQOL (standardized beta = .42, P < .001), after controlling for functional status, demographics, and clinical variables.
Conclusions: We found the trajectory of depressive symptoms predicts future HROOL. Research is needed to determine whether interventions targeting depressive symptoms improve HRQOL in patients with HF. (J Cardiac Fail 2011;17:755-763)

• 出版日期2011-9