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摘要
Aims: This study aims to investigate the prevalence of human papillomavirus (HPV) genotypes and analyze the relationship of HPV infectious status to clinicopathologic characteristics of invasive cervical carcinoma (ICC) in Zhejiang Province. Materials and Methods: All consecutive patients diagnosed with the International Federation of Gynecology and Obstetrics stage IA to IV ICC, treated at our institutions between January 2007 and December 2008 were enrolled. The associations between the clinicopathologic parameters and the HPV status were assessed by the Pearson Chi-square test. Results: Out of 1169 patients, 1072 (91.70%) patients had detectable HPV, the HPV-positive rate seemed to be higher as the severity of pathology increased and preferred to squamous cell carcinoma (SCC). HPV-16/-58/-18/-52 was the most prevalent types found in Zhejiang Province. HPV-16 was preferred to SCC (P = 0.049), while HPV-58 seemed to be more likely in non-SCC (P = 1.18E-6), deep stromal invasion (DSI)-positive (P = 0.001), lymphovascular space invasion (LVSI)-positive (P = 4.84E-6), and lymph node metastasis (LNM)-positive (P = 7.98E-4). HPV-52 was more common in surgery patients who were beyond 35 years old (P = 0.02), as well as in DSI-positive (P = 0.014) patients. However, there were no significant differences regarding HPV-58 to any clinicopathologic parameters. Conclusions: HPV-16/-18/-58/-52 was the most commonly identified types in Zhejiang Province, which contributed for vaccine development. Furthermore, HPV-16 was preferred to SCC, while HPV-58 seemed to be more likely in non-SCC, DSI-positive, LVSI-positive, and LNM-positive patients, and HPV-52 was more common in surgery patients who were beyond 35 years old, as well as in DSI-positive patients.
- 出版日期2018
- 单位浙江省肿瘤医院
