Nucleophilic Substitution of Secondary Alkyl-Substituted Propargyl Acetates: An Economic and Practical Indium Trichloride Catalyzed Access

作者：Lin Min; Hao Lu; Liu Xiao tao; Chen Qing zhen; Wu Feng; Yan Ping; Xu Su xia; Chen Xin liang; Wen Jia jie; Zhan Zhuang ping^*

来源：Synlett, 2011, (5): 665-670.

DOI：10.1055/s-0030-1259557

• propargyl acetate
• nucleophilic substitution
• indium
• propargyl cycloether

An economic and practical transformation from secondary alkyl-substituted propargyl acetates to a variety of nucleophilic substitution products was described. This reaction was catalyzed by inexpensive InCl3. High yields and excellent chemoselectivity were obtained. The five-, six-, and seven-membered propargyl cycloethers were also successfully constructed by this protocol.

• 出版日期2011-3
• 单位厦门大学