A New Benzophenanthridine Alkaloid from Caloncoba glauca

作者：Agbo Jabar B P A A; Mpetga James D S; Bikanga Raphael; Tchuenguem Roland T; Tsafack Rolande B N; Awouafack Maurice D; Dzoyem Jean P; Ito Takuya; Morita Hiroyuki; Tane Pierre^*

来源：Natural Product Communications, 2017, 12(3): 367-368.

DOI：10.1177/1934578x1701200314

• Caloncoba glauca
• Flacourtiaceae
• Benzophenanthridine alkaloid
• N-formyldihydrochelerythrine
• Antimicrobial

Three alkaloids including a new one, N-formyldihydrochelerythrine (1), together with four other known compounds were isolated from the stem bark of Caloncoba glauca. The structure of the new compound was elucidated from spectroscopic and mass spectrometric evidence. This is the first report of alkaloids from the genus Caloncoba. Sesamin (4) [MIC = 256 mu g/mL (Candida albicans) and dihydrochelerythrine (2) [MIC = 32 (C. albicans and C. parapsilosis), and 128 mu g/mL (C. krusei)] had moderate to weak antifungal activity.

• 出版日期2017-3