Elucidating the Structural Isomerism of Fluorescent Strigolactone Analogue CISA-1

作者：Goossens Hannelore; Heugebaert Thomas S A; Dereli Busra; Van Overtveldt Melissa; Karahan Ozlem; Dogan Ilknur; Waroquier Michel; Van Speybroeck Veronique; Aviyente Viktorya; Catak Saron^*; Stevens Christian V

来源：European Journal of Organic Chemistry, 2015, 2015(6): 1211-1217.

DOI：10.1002/ejoc.201403457

• Atropisomerism
• Lactones
• Conformation analysis
• Configuration determination
• Density functional calculations

The synthesis of a new potent strigolactone analogue (CISA-1), resulting in the formation of two interconverting structural isomers, which could not be identified, was recently reported. In the present study, a combined computational and experimental approach is used to identify the exact nature of these structural isomers. Although standard experimental techniques could not be used to determine the identity of the isomers, chromatographic methods excluded E/Z isomerisation. Computational H-1 NMR chemical shift values and DFT calculations on interconversion barriers strongly suggest that the CISA-1 isomers were interconverting (Z)-configured atropisomers.

• 出版日期2015-2