Approaching Tumor Tissue in Local Blood Vessel for Targeted Drug Delivery by Nanorobots

作者：Qingying, Zhao; Min, Li; Jun, Luo; Hanqing, Wang; Jinge, Cao

来源：Journal of Computational and Theoretical Nanoscience, 2016, 13(10): 6654-6661.

DOI：10.1166/jctn.2016.5611

<jats:p>This paper describes a nanorobot control algorithm designed for approaching tumor tissue in local blood vessel for targeted drug delivery. The algorithm coordinates nanorobots’ movements through use of two types of chemical molecules, an acoustic signal and velocity characteristic
of blood fluid. After detecting the chemical molecules released by cancer cells, a nanorobot moves toward the area of higher concentration of the molecule and releases another chemical molecule which alerts others to aggregate to the target. When nanorobots detect acoustic signals emitted
by nanorobots reaching target, their paths will be planned according to intensity of acoustic signals and velocity characteristic of blood fluid. The simulations show that compared with the existed approaches, the proposed algorithm results in an increase of nanorobots’ population and
a decrease of cost time to reach target site with the help of acoustic signals and velocity characteristic. As a whole, the results obtained suggest that the algorithm presented in this paper is a better strategy for approaching tumor tissue in local blood vessel by nanorobots.</jats:p>

• 出版日期2016-10-1
• 单位上海大学