Association between the Use of Blood Components and the Five-Year Mortality after Liver Transplant

作者：de Morais Bruno Salome^*; Sanches Marcelo Dias; Ribeiro Daniel Dias; Lima Agnaldo Soares; de Abreu Ferrari Teresa Cristina; de Freitas Duarte Malvina Maria; Gomes Moreira Cancado Guilherme Henrique

来源：Revista Brasileira de Anestesiologia, 2011, 61(3): 286-292.

• Blood Component Transfusion
• Liver Transplantation
• Fatal Outcome

The Summary: Morais BS, Sanches MD, Ribeiro DD, Lima AS, Ferrari TCA, Duarte MMF, Cancado GHGM - Association between the Use of Blood Components and the Five-Year Mortality after Liver Transplant.
Background and objectives: Liver transplant (LT) surgery is associated with significant bleeding in 20% of cases, and several authors have demonstrated the risks related to blood components. The objective of the present study was to evaluate the impact of using blood components during hospitalization in five-year survival of patients undergoing LT.
Methods: One hundred and thirteen patients were evaluated retrospectively. Several variables, including the use of blood components intraoperatively and throughout hospitalization, were categorized and evaluated by univariate analysis using Fisher's test. A level of significance of 5% was adopted. Results with p < 0.2 underwent multivariate analysis using multinomial logistic regression.
Results: Parenchymal diseases, preoperative renal dysfunction, and longer stay in hospital and ICU are associated with greater five-year mortality after LT (p < 0.05). Unlike the intraoperative use of blood components, the accumulated transfusion of packed red blood cell, frozen fresh plasma, and platelets during the entire hospitalization was associated with greater five-year mortality after liver transplantation (p < 0.01).
Conclusions: This study emphasizes the relationship between the use of blood components during hospitalization and increased mortality in five years after LT.

• 出版日期2011-6