Asymmetric synthesis of optically active 3-amino-1,2-diols from N-acyl-protected allylamines via catalytic diboration with Rh[bis(oxazolinyl)phenyl] catalysts

作者：Toribatake Kenji; Miyata Suguru; Naganawa Yuki; Nishiyama Hisao^*

来源：Tetrahedron, 2015, 71(21): 3203-3208.

DOI：10.1016/j.tet.2015.04.011

• Asymmetric
• Rhodium
• Bis(oxazoline)
• Boration
• 1,2-Diol

Asymmetric diboration of N-acyl-protected allylamines such as substituted imides, amides, and carbamates catalyzed by chiral rhodium[bis(oxazolinyl)phenyl] complexes followed by oxidation in one-pot was realized to produce optically active 3-amino-1,2-propanediol derivatives in high enantioselectivities up to 99%.

• 出版日期2015-5-27