ANTIHYPERLIPIDEMIC EFFECT OF PEUCEDANUM PASTINACIFOLIUM EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

作者：Movahedian Ahmad^*; Zolfaghari Behzad; Sajjadi S Ebrahim; Moknatjou Reza

来源：Clinics, 2010, 65(6): 629-633.

DOI：10.1590/S1807-59322010000600011

• P. pastinacifolium
• Lipoproteins
• Cholesterol
• Hypercholesterolemia

INTRODUCTION: Dyslipidemia is one of the most common complications of diabetes mellitus, significantly contributing to cardiovascular morbidity and mortality in diabetic patients. Peucedanum pastinacifolium Boiss. & Hausskn. is commonly used as an antihyperlipidemic vegetable in Iranian folk medicine. MATERIAL AND METHODS: In this study, we examined a hydroalcoholic extract of the aerial parts of Peucedanum pastinacifolium to determine its lipid-lowering activity in normal and streptozotocin (STZ)-induced diabetic rats. Experimental diabetes mellitus was induced by a single intraperitoneal administration of streptozotocin. Normal and streptozotocin-induced diabetic rats were separated into four groups. The groups were fed with 0, 125, 250 or 500 mg/kg body weight of Peucedanum Pastinacifolium hydroalcoholic Extract (PPE) in aqueous solution for 30 days. RESULTS: The results show that there were significant (P < 0.05) increases in total serum cholesterol, triglyceride and low-density lipoprotein cholesterol (LDL-C) and a decrease in high-density lipoprotein cholesterol (HDL-C) in streptozotocin-induced diabetic rats. Treatment of diabetic rats with PPE over a period of a month returned these levels close to control levels. CONCLUSION: These results suggest that PPE has hypolipidemic effects in streptozotocin-induced diabetic rats.

• 出版日期2010-6