A novel 'domino-click approach' to unsymmetrical bis-1H-1,2,3-triazoles

作者:Banday Abid H; Arora Bhupinder S; Alam Mohammed S; Kumar Halmuthur M Sampath*
来源:Helvetica Chimica Acta, 2007, 90(12): 2368-2374.
DOI:10.1002/hlca.200790242

摘要

Aryl azides 1 were treated with allenylmagnesium bromide (2) to generate 1,5-disubstituted butynyl-1H-1,2,3-triazoles 3 in a domino fashion, which upon Cu-1-catalyzed 1,3-dipolar cycloaddition with aryl azides 4 afforded novel bis-1H-1,2,3-triazoles 5 in quantitative yields (Scheme 1 and Table).

  • 出版日期2007