mTOR and its tight regulation for iNKT cell development and effector function

作者：Yang Wei; Gorentla Balachandra; Zhong Xiao Ping; Shin Jinwook

来源：Molecular Immunology, 2015, 68(2): 536-545.

DOI：10.1016/j.molimm.2015.07.022

• iNKT cell
• mTOR
• Raptor
• Rictor
• TSC1/2
• Diacylglycerol kinases
• RasGRP1
• PTEN
• Ras
• CARMA1
• iNKT1
• iNKT2
• iNKT17
• Signal transduction

Invariant NKT (iNKT cells, which express the invariant V alpha 14J alpha 18 TCR that recognizes lipid antigens, have the ability to rapidly respond to agonist stimulation, producing a variety of cytokines that can shape both innate and adaptive immunity. iNKT cells have been implicated in host defense against microbial infection, in anti-tumor immunity, and a multitude of diseases such as allergies, asthma, graft versus host disease, and obesity. Emerging evidence has demonstrated crucial role for mammalian target of rapamycin (mTOR) in immune cells, including iNKT. In this review we will discuss current understanding of how mTOR and its tight regulation control iNKT cell development, effector lineage differentiation, and function.

• 出版日期2015
• 单位河北医科大学