Natural killer T cells suppress zymosan A-mediated granuloma formation in the liver by modulating interferon-? and interleukin-10

作者：Kobayashi Takahiro; Kawamura Hiroki; Kanda Yasuhiro; Matsumoto Hiroaki; Saito Suguru; Takeda Kazuyoshi; Kawamura Toshihiko; Abo Toru^*

来源：Immunology, 2012, 136(1): 86-95.

DOI：10.1111/j.1365-2567.2012.03562.x

• granuloma
• interferon-
• liver
• natural killer T cells
• zymosan A

Wild-type (WT) and CD1d-/- [without natural killer (NK) T cells] mice were treated with zymosan A to induce granuloma formation in the liver. Increased granuloma formation was seen in NKT-less mice on days 7 and 14 after administration. WT mice showed limited granuloma formation, and zymosan A eventually induced NKT cell accumulation as identified by their surface marker (e.g. CD1d-tetramer). Zymosan A augmented the expression of Toll-like receptor 2 on the cell surface of both macrophages and NKT cells. One possible reason for accelerated granuloma formation in NKT-less mice was increased production of interferon- ? (IFN-?); a theory that was confirmed using IFN-?-/- mice. Also, zymosan A increased interleukin-10 production in WT mice, which suppresses IFN-? production. Taken together, these results suggest that NKT cells in the liver have the potential to suppress zymosan A-mediated granuloma formation.

• 出版日期2012-5