A wearable potentiometric sensor with integrated salt bridge for sweat chloride measurement

作者：Choi Dong Hoon; Li Yi; Cutting Garry R; Searson Peter C^*

来源：Sensors and Actuators B: Chemical , 2017, 250: 673-678.

DOI：10.1016/j.snb.2017.04.129

• Potentiometric sensor
• Wearable sensor
• Sweat chloride
• Cystic fibrosis

The development of wearable sensors to measure biomarkers in sweat remains a major technological challenge. Here we report on a wearable, potentiometric, thin film sweat chloride sensor. Potentiometric devices provide a relatively simple technology for sweat sensing, however, equilibration between the reference and test solutions is a significant source of error. We have developed a sweat chloride sensor with integrated salt bridge that minimizes equilibration and enables stable measurements over extended periods of time. The sensor shows a very small concentration drift even with small sample volumes. The measurement variation was less than 2 mM at low chloride ion concentration (10 mM) and 5 mM at high concentration (150 mM), spanning the range for healthy individuals and CF patients. Finally, in on-body tests we show that the sweat chloride concentration in healthy individuals is dependent on exercise intensity, indicating that the sensor has a potential for a fitness monitoring applications.

• 出版日期2017-10