Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

作者：Xie Yuli; Liu Yidong; Gong Gangli; Smith Deborah H; Yan Fang; Rinderspacher Alison; Feng Yan; Zhu Zhengxiang; Li Xiangpo; Deng Shi Xian; Branden Lars; Vidovic Dusica; Chung Caty; Schuerer Stephan; Morisseau Christophe; Hammock Bruce D; Landry Donald W^*

来源：Bioorganic & Medicinal Chemistry Letters, 2009, 19(8): 2354-2359.

DOI：10.1016/j.bmcl.2008.09.066

• sEH
• Non-urea
• HTS
• Nanomolar

Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC(50)s of the most potent compounds range from micromolar to low nanomolar.

• 出版日期2009-4-15