A short practical approach to 24R,25-dihydroxyvitamin D-3

作者：Nicoletti Daniel; Gregorio Carlos; Mourino Antonio; Maestro Miguel^*

来源：Journal of Steroid Biochemistry and Molecular Biology, 2010, 121(1-2): 43-45.

DOI：10.1016/j.jsbmb.2010.03.071

• 24R,25-Dihydroxyvitamin D-3
• Wittig-Horner approach
• [3,3]-Sigmatropic rearrangement
• Catalytic palladium(0)

A synthesis of the vitamin D-3 metabolite 24R,25-dihydroxyvitamin D-3 (1) by Lythgoe's Wittig-Horner approach is described. The key step of the synthesis is the stereocontrolled introduction of the 24-hydroxyl group by a palladium(0)-induced [3,3]-sigmatropic rearrangement on a 22R-allylic acetate (7).

• 出版日期2010-7