Absolute Ligand Discrimination by Dimeric Signaling Receptors

作者：Fathi Sepehr; Nayak Chitra R; Feld Jordan J; Zilman Anton G

来源：Biophysical Journal, 2016, 111(5): 917-920.

DOI：10.1016/j.bpj.2016.07.029

Many signaling pathways act through shared components, where different ligand molecules bind the same receptors or activate overlapping sets of response regulators downstream. Nevertheless, different ligands acting through cross-wired pathways often lead to different outcomes in terms of the target cell behavior and function. Although a number of mechanisms have been proposed, it still largely remains unclear how cells can reliably discriminate different molecular ligands under such circumstances. Here we show that signaling via ligand-induced receptor dimerization a very common motif in cellular signaling naturally incorporates a mechanism for the discrimination of ligands acting through the same receptor.

• 出版日期2016-9-6