Nanoparticle generation by intensified solution crystallization using cold plasma

作者：Radacsi N; van der Heijden A E D M; Stankiewicz A I; ter Horst J H^*

来源：Chemical Engineering and Processing, 2013, 71: 51-58.

DOI：10.1016/j.cep.2013.03.002

• Nanoparticle synthesis
• Cold plasma
• Process intensification
• RDX
• API
• Niflumic acid
• Crystallization

In this study, atmospheric pressure cold plasma (surface dielectric barrier discharge) was used as an alternative energy form to intensify solution crystallization and produce nano-sized organic crystals. Nano-sized particles can have beneficial product properties such as improved internal quality and dissolution rate, compared to conventionally sized crystalline products. In cold plasma intensified crystallization a nebulizer system sprays the solution aerosol into the plasma with the help of a carrier gas. The plasma simultaneously heats and charges the droplets causing fast solvent evaporation and Coulomb-fission to occur, after which nucleation and crystal growth commence within the small, confined volume offered by the small droplets. In this manner, nano-sized crystals of the energetic material RDX and the pharmaceutical niflumic acid were produced.

• 出版日期2013-9