New Triterpenoids and Other Constituents from a Special Microbial-Fermented Tea-Fuzhuan Brick Tea

作者：Ling, Tie-Jun; Wan, Xiao-Chun^*; Ling, Wei-Wei; Zhang, Zheng-Zhu; Xia, Tao; Li, Da-Xiang; Hou, Ru-Yan

来源：Journal of Agricultural and Food Chemistry, 2010, 58(8): 4945-4945.

DOI：10.1021/jf9043524

• Fuzhuan brick tea
• Camellia sinensis var. sinensis
• triterpenoids
• antibacterial activities
• cytotoxic activity

Fuzhuan brick tea, a special microbial-fermented tea prepared from the leaves of Camellia sinensis var. sinensis, is a traditional beverage used in China throughout history. Phytochemical investigation of this material led to the identification of three new triterpenoids, 3 beta,6 alpha,13 beta-trihydroxyolean-7-one (1), 3 beta-acetoxy-6 alpha,13 beta-dihydroxyolean-7-one (2), and 3 beta-O-(8-hydroxyoctanoyl)-12-oleanene (3), together with 11 known compounds, friedelin (4), beta-amyrone (5), beta-amyrin (6), alpha-spinasterone (7), alpha-spinasterol (8), 22,23-dihydro-alpha-spinasterone (9), 22,23-dihydro-alpha-spinasterol (10), alpha-phytol (11), alpha-tocopherol (12), alpha-tocoquinone (13), and caffeine (14). The structures of 1-13 were determined by spectroscopic and chemical methods. Compounds 1 and 2 are the first two examples of triterpenoids possessing a 6-hydroxy-7-one function. All of the compounds, except 6, 8, 10, 11, and 14, were isolated from tea and Camellia spp. for the first time. The antibacterial activities of 1 were assessed against some enteric pathogenic microbes. Compound 1 showed no cytotoxic activity against A-549, Bel-7402, and HCT-8 cell lines.

• 出版日期2010-4-28
• 单位安徽农业大学