Meta-analysis of factor V Leiden and prothrombin G20210A polymorphism in migraine

作者：Lippi Giuseppe^*; Mattiuzzi Camilla; Cervellin Gianfranco

来源：Blood Coagulation & Fibrinolysis, 2015, 26(1): 7-12.

DOI：10.1097/MBC.0000000000000188

• FII G20210A
• FV Leiden
• headache
• migraine
• prothrombin

Migraine is a frequent and disabling condition, which exhibits a substantial genetic background and is frequently associated with abnormalities of primary and secondary hemostasis. We performed a systematic literature search and a meta-analysis of available data about the potential associations between migraine and factor V (FV) Leiden or prothrombin (FII) G20210A gene polymorphism. The final number of studies included was 15 (all cross-sectional) about migraine and FV Leiden, and 12 (all cross-sectional) about migraine and FII G20210A polymorphism, with broad inter-study heterogeneity (I-2, 82 and 85%). The cumulative prevalence of the FV 1691A allele was found to be similar between cases (n=1450; 4.9%) and controls (n=3468; 4.7%; P=0.74). The cumulative prevalence of the FII 20210A allele was also found to be similar between cases (n=1226; 4.2%) and controls (n=3144; 4.5%; P=0.59). Nevertheless, sub-analysis of studies in adults and children revealed that both polymorphisms were not associated with migraine in adults, but FV Leiden and the FII 20210A allele were approximately two-fold more prevalent in children with migraine than in those without. In conclusion, despite migraine exhibits a clear neurovascular origin and is frequently associated with thrombotic disorders, isolate thrombophilic mutations seem to play a negligible pathogenetic role in this condition in adults, whereas the increased prevalence of FV Leiden and the FII 20210A allele in children with migraine deserves further scrutiny.

• 出版日期2015-1