Acute lymphoblastic leukemia in infants: 20 years of experience

作者：Ibagy Amanda^*; Silva Denise B; Seiben Jackline; Winneshoffer Ana P F F; Costa Tatiana E J B; Dacoregio Juliana S; Costa Imarui; Faraco Daniel

来源：Jornal de Pediatria, 2013, 89(1): 64-69.

DOI：10.1016/j.jped.2013.02.010

• Infant
• Leukemia, classification
• Precursor cell lymphoblastic leukemia-lymphoma

Objective: To analyze patients younger than 2 years with acute lymphoblastic leukemia, treated in the period between 1990 and 2010 in a state reference center.
Methods: This was a clinical-epidemiological, cross-sectional, observational, and descriptive study. It included patients younger than 2 years with acute lymphoblastic leukemia, treated in the period of 1990 to 2010 in a pediatric oncology unit of a state reference center, totaling 41 cases.
Results: All patients were white ethnicity, and 60.9% were females. Regarding age, 24.38% were younger than 6 months, 17.07% were between 6 months and 1 year, and 58.53% were older than 1 year. The age of 6 months was statistically significant for the outcome of death. Predominant signs and symptoms were fever, bruising, and petechiae. A leukocyte count > 100,000 was found in 34.14% of cases, hemoglobin count < 11 in 95.13%, and platelet count < 100,000 in 75.61. Infiltration of central nervous system was present in 12.91% of patients. According to the lineage, B-cell lineage predominated (73%), but the T-cell line was statistically significant for death. 39% of patients had disease recurrence. In relation to vital status, 70.73% of the patients died; septic shock was the main cause.
Conclusions: Acute lymphoblastic leukemia in infants has a high mortality rate, especially in children under 1 year and those with T-cell derived lineage.

• 出版日期2013-2