Gold nanoparticles as a versatile platform for optimizing physicochemical parameters for targeted drug delivery

作者：Bergen Jamie M; Von Recum Horst A; Goodman Thomas T; Massey Archna P; Pun Suzie H^*

来源：Macromolecular Bioscience, 2006, 6(7): 506-516.

DOI：10.1002/mabi.200600075

• drug delivery systems
• gold colloids
• liver
• nanoparticles
• targeting

The development of targeted vehicles for systemic drug delivery relies on optimizing both the cell-targeting ligand and the physicochemical characteristics of the nanoparticle carrier. A versatile platform based on modification of gold nanoparticles with thiolated polymers is presented in which design parameters can be varied independently and systematically. Nanoparticle formulations of varying particle size, surface charge, surface hydrophilicity, and galactose ligand density were prepared by conjugation of PEG-thiol and galactose-PEG-thiol to gold colloids. This platform was applied to screen for nanoparticle formulations that demonstrate hepatocyte-targeted delivery in vivo. Nanoparticle size and the presence of galactose ligands were found to significantly impact the targeting efficiency. Thus, this platform can be readily applied to determine design parameters for targeted drug delivery systems.

• 出版日期2006-7-14