Association of Glycemic Index and Glycemic Load With Risk of Incident Coronary Heart Disease Among Whites and African Americans With and Without Type 2 Diabetes: The Atherosclerosis Risk in Communities Study

作者：Hardy Dale S; Hoelscher Deanna M; Aragaki Corinne; Stevens June; Steffen Lyn M; Pankow James S; Boerwinkle Eric^*

来源：Annals of Epidemiology, 2010, 20(8): 610-616.

DOI：10.1016/j.annepidem.2010.05.008

• African Americans
• Coronary Heart Disease
• Glycemic Index
• Glycemic Load
• Race
• Type 2 Diabetes
• Whites

PURPOSE: In this study we examined whether high glycemic index (Cl) and glycemic load (GL) diets are associated with increased risk of developing coronary heart disease (CHD) in Whites and African Americans with and without type 2 diabetes.
METHODS: Data on 13,051 patients ages 45 to 64 years from the Atherosclerosis Risk in Communities study were analyzed. The ARIC food frequency questionnaire baseline data provided GI and GL indices. A propensity score was created to estimate the effect of a patient's covariates on energy-adjusted GI or GL. During a maximum of 17 years of follow-up, 1683 cases of CHD (371 with diabetes and 1312 without diabetes) were recorded.
RESULTS: For every 5-units increase in Cl, there was a 1.16-fold (95% confidence interval 195% Cl], 1.01-1.33) increased risk of incident CHD in African Americans. For every 30-units increase in GL, there was a 1.11-fold (95% CI, 1.01-1.21) increased risk of incident CL-ID in Whites. High GL was an especially important CHID risk factor for Whites without diabetes (per 30-units increase; hazard ratio, 1.14; 95% Cl, 1.02-1.26). However, these relationships were not seen in individuals with diabetes.
CONCLUSIONS: Nutritional advice to reduce the Cl and GL in diets of African Americans and Whites subjects (without diabetes) may play a role in reducing CHD risk. Ann Epidemiol 2010;20:610-616.

• 出版日期2010-8