Age Modifies the Effect of 2-MeV Fast Neutrons on Rat Mammary Carcinogenesis

作者：Imaoka Tatsuhiko^*; Nishimura Mayumi; Daino Kazuhiro; Hosoki Ayaka; Takabatake Masaru; Kokubo Toshiaki; Doi Kazutaka; Showler Kaye; Nishimura Yukiko; Moriyama Hitomi; Morioka Takamitsu; Shimada Yoshiya^*; Kakinuma Shizuko^*

来源：Radiation Research, 2017, 188(4): 419-425.

DOI：10.1667/RR14829.1

The relative biological effectiveness (RBE) of neutrons depends on their physical nature (e.g., energy) and the biological context (e.g., end points, materials). From the perspective of radiological protection, age is an important biological context that influences radiation-related cancer risk, but very few studies have addressed its potential impact on neutron effects. We therefore investigated the influence of age on the effect of accelerator-generated fast neutrons (mean energy, similar to 2 MeV) in an animal model of breast carcinogenesis. Female Sprague-Dawley rats at 1, 3 and 7 weeks of age were irradiated with fast neutrons at absorbed doses of 0.0485-0.97 Gy. All animals were kept under specific pathogen-free conditions and screened weekly for mammary tumors by palpation until they were 90 weeks old. Tumors were diagnosed based on histology. Mathematical modeling was used to analyze mammary cancer incidence, collectively using data from this study and a previously reported experiment on Cs-137 gamma rays. The results indicate that neutron irradiation elevated the risk of palpable mammary carcinoma with a linear dose response, the slope of which depended on age at time of irradiation. The RBE of neutron radiation was 7.5 +/- 3.4, 9.3 +/- 3.5 and 26.1 +/- 8.9 (mean +/- SE) for animals exposed at 1, 3 and 7 weeks of age, respectively. Our results indicate that age of the animal is an important factor influencing the effect of fast neutrons on breast cancer risk.

• 出版日期2017-10